Nanhi Kali Celebrates 9th Proud Fathers for Daughters Edition
Chandigarh, January 24, 2025: The ninth edition of Proud Fathers For Daughters, an annual fundraising event by Project Nanhi Kali, took place on January 11 and 12, 2025 at the National Sports Club of India, Worli, Mumbai. The event witnessed an extraordinary turnout of 265 father-daughter duos from across the country, with 527 portraits captured during the two-day event. The proceeds from the event will go towards the education of 527 underserved girls, empowering them with opportunities for a brighter future.
Proud Fathers For Daughters was founded by Anand Mahindra, Chairperson of the Mahindra Group and K.C. Mahindra Education Trust, and renowned photographer Atul Kasbekar to shift societal mindsets towards the girl child and reinforce the importance of gender equality. The event challenges entrenched stereotypes, showcasing fathers not just as caregivers, but as active champions of their daughters’ dreams, ambitions, and independence. It’s a powerful reminder that when fathers support their daughters wholeheartedly, they unlock limitless potential, breaking down barriers for future generations.
Since its inception, Proud Fathers For Daughters has become a symbol of hope and empowerment, creating 2,397 stunning portraits that celebrate a father’s unwavering support for his daughter’s dreams. Each portrait tells a powerful story of love, encouragement, and the belief in a brighter future for all girls. Through the funds raised at the event through the years, Project Nanhi Kali has been able to support the education of over 5,597 underserved girls, giving them the tools to break barriers of inequality, pursue their ambitions, and rewrite their stories.
This year’s theme, “Her First Coach,” drew inspiration from Project Nanhi Kali’s new curriculum, which focuses on 21st-century skills and sports leadership to foster holistic development in girls. The event highlighted the pivotal role fathers play as their daughters’ first guides, mentors, and cheerleaders and encourage fathers to championing their daughters dreams and ambitions.
Renowned photographers Atul Kasbekar, Colston Julian, Jaideep Oberoi, Prasad Naik, Rafique Sayed, Tarun Vishwa, and Tejal Patni generously dedicated their time, talent, and creative expertise to make Proud Fathers For Daughters a truly unforgettable event. These celebrated photographers came together not only to capture tender moments of pride and joy between fathers and daughters but also to champion a transformative cause. By lending their skills to this initiative, they turned every portrait into a cherished memory, while underscoring the power of storytelling through photography to inspire change and drive impact. Their commitment to using their art for social good added a profound depth to the event, amplifying its message of empowerment and hope.
Participants contributed INR 10,000 for a professional father-daughter photoshoot, with each contribution funding the education of one underserved girl for an entire year at Project Nanhi Kali. Beyond providing education and skilling, Project Nanhi Kali’s updated curriculum emphasises leadership through sports, teamwork, and critical thinking, preparing girls to thrive in the 21st-century.
Sheetal Mehta, Executive Director at Project Nanhi Kali and Senior Vice President, CSR, Mahindra, remarked: “At Project Nanhi Kali, we are committed to creating an ecosystem where girls are empowered to dream big. Through our new curriculum, we equip girls with 21st-century skills and sports leadership skills, enabling them to lead and succeed. The theme of this year’s Proud Fathers For Daughters—‘Her First Coach’—beautifully underscores the important role fathers play in shaping their daughters into future leaders. We are deeply touched by the overwhelming response and thank the participants for their unwavering support towards our cause through the years. Not to forget, we extend our heartfelt gratitude to the photographers for their creativity and unwavering support. This edition’s success reaffirms the belief that when families and communities champion a girl’s dreams, the impact is transformative—not just for her, but for society at large.”
Yami Gautam Joins Piramal Pharma’s Brand Little’s
Chandigarh, January 24, 2025 – Piramal Pharma Limited’s India Consumer Healthcare (ICH) today announced the launch of its new campaign, #SwitchToSofter, for its flagship baby care brand, Little’s®. The campaign features actress Yami Gautam as the brand’s new ambassador and introduces Little’s Fluffy Soft Diaper Pants—crafted with superior imported materials to ensure 12-hour absorption, an anti-rash formula, and a wetness indicator for all-round protection and enhanced softness for babies.
Young mothers often turn to family, friends, and their social circles instead of actually conducting proper research themselves, when selecting baby products. Brand Little’s aims to break this trend by convincing mothers to make an informed choice by trying the brand which promises to give smoother and softer diapers, which can be felt tangibly. The brand strongly conveys this message through a #SwitchToSofter campaign with their new brand ambassador Yami Gautam. To further assure the consumers on product quality, the brand is offering a money back guarantee if the consumer is not happy with the product, thus building more confidence.
Sai Ramana Ponugoti, CEO, Piramal Consumer Healthcare said, “With the rise of urbanization, greater exposure to global trends, and growing awareness about child health and hygiene, the expectations of new mothers in India have increased significantly for baby care products. Today, new mothers demand a diaper that guarantees not only absorption but also gentle softness to protect delicate baby skin. Little’s Fluffy Soft Diaper Pants have been thoughtfully designed to meet these needs with comfort, protection, and innovation.”
Speaking on this association with Little’s, Yami Gautam said, “As a new mother, I am incredibly happy to partner with Little’s, a brand that truly understands the needs of both babies and mothers. Motherhood is a beautiful yet challenging journey, and having Little’s by my side makes it easier. The launch of Little’s Fluffy Soft Diaper Pants exemplifies their commitment to ultimate comfort, enriching the softness experience for babies. This focus on comfort helps keep my baby relaxed, allowing me to enjoy motherhood with less stress.”
Little’s, founded in the 1980s, has built a strong legacy as a trusted name in baby care. Over the past three decades, it has become one of India’s most beloved brands for baby products, gaining the confidence of Indian mothers. The brand offers a comprehensive range of products catering to babies from birth to 2 years of age, addressing their diverse needs at different life stages. Its product portfolio includes diapers, wipes, feeding, toys & baby personal care, all of which are widely used and recommended by parents. Little’s has earned a reputation for providing reliable and high-quality products to support babies’ well-being and growth.
True Crime: Indian Tales for ‘Black Warrant’ Fans
What is it about true crime that keeps us on the edge of our seats? From chilling documentaries to gripping audiobooks, the genre has a way of pulling us into the minds of criminals and the intricate webs of justice. In India, the love for true crime has skyrocketed, with series like ‘Black Warrant,’ created by the incredibly talented Vikramaditya Motwane and Satyanshu Singh, starring Zahan Kapoor, attracting audiences recently. And, for those who can’t get enough, there’s a world of true crime audiobooks, films, and series waiting to be explored—each unraveling mysteries that are as fascinating as they are unsettling. Whether you’re a seasoned crime junkie or just dipping your toes into the genre, these stories will leave you spellbound.
Unfound: True Crime Mysteries of India
It is an intriguing Audible Original podcast series that delves into real-life crimes that have baffled investigators across the country. From shocking abductions to chilling murders, each episode uncovers a new mystery that leaves listeners on the edge of their seats. ‘The Serial Killer’ episode follows the mysterious disappearance of 14-year-old Maltu Agarwal in Calcutta, after he meets a stranger who promises him an acting role, only for him to vanish without a trace. The series continues with ‘The Invisible Yogi,’ a mind-boggling tale of a Himalayan Yogi who manipulated India’s financial world before disappearing into thin air. Many more such intriguing cases await you on this series.
Death Served Cold
Behind seemingly ordinary lives lie extraordinary tales of darkness. ‘Death Served Cold’ written by popular author Sourabh Mukherjee unearths the chilling truths about India’s most dangerous women. Through meticulously researched true stories, it reveals horrifying accounts of those who committed cold-blooded murders over the past three decades. From a wife savoring her husband’s last cries on the phone as he’s killed by her lover, to a teacher harboring a deadly secret for 14 years, these narratives shatter stereotypes about female aggression. A gripping exploration of the human psyche!
Godfathers of Crime
In Godfathers of Crime, journalist Sheela Raval recounts her fearless three-decade pursuit of India’s most infamous gangsters. Through her personal encounters and bold reporting, she unveils the inner workings of the D Company, the split between Dawood and Chhota Rajan, and the rise of organized crime with global connections. Bold and revealing, this audiobook gives an unprecedented glimpse into a shadowy world that has shaped India’s underworld.
The Deadly Dozen
Think serial killers are only a Western phenomenon? ‘The Deadly Dozen’ shatters that myth with chilling stories of India’s most sinister murderers! From a schoolteacher who poisoned multiple lovers to a mother who turned her daughters into child-killers, and even a 19th-century thug who claimed over 900 lives, these accounts delve deep into their twisted motives and chilling deeds. Prepare for a journey into the dark recesses of human nature that will leave you questioning what truly drives people to kill.
Khooni: The Crimes of India
Ever wondered about the chilling crimes that lurk in the darkest corners of India? Khooni – The Crimes of India Podcast takes you deep into the heart of these unsettling tales, narrated by two Indian girls who explore the sordid details of each case with a touch of suspense, humour, and a fresh perspective. With each episode, they bring the most riveting stories to light and keep you on the edge of your seat. Whether you’re a true crime aficionado or looking for an intriguing listen during their commute, this podcast is sure to leave you questioning the mysteries that lie beneath.
No One Killed Jessica
Set in 1999 New Delhi, this film chronicles the story of the tragic death of a young model named Jessica which shook the nation. After refusing to serve a drink at a celebrity party, Jessica is fatally shot by Manish, the son of a powerful politician, who feels untouchable due to his privilege. As Jessica’s sister fights for justice against the odds, this film unravels a tale of corruption, power, and an unyielding quest for truth. It’s a reminder of the lengths some must go to when the system fails them.
Dahaad
In ‘Dahaad,’ sub-inspector Anjali Bhaati is called to investigate the mysterious deaths of women in public bathrooms, initially believed to be suicides. However, as the case unfolds, Anjali suspects a serial killer is at work, setting the stage for a tense chase. As a determined cop facing unexpected challenges, she must use all her wit and experience to uncover the truth, while grappling with a dangerous criminal. A tale of suspense, this thriller will keep you on the edge.
The Hunt for Veerappa
This is a gripping docuseries that unravels the life of Veerappan, one of South India’s most notorious smugglers. Through four intense episodes, it traces his rise to power, his bloody battles with law enforcement, and the 20-year manhunt that ultimately brought him down. From violent clashes in the forest to the high-stakes abduction of a beloved movie star, this series offers a chilling yet fascinating glimpse into a criminal empire and its eventual collapse. A must-watch for anyone intrigued by true crime tales!
Curry & Cyanide: The Jolly Joseph Case
‘Curry & Cyanide: The Jolly Joseph Case’ delves into the chilling true-crime story of six deaths within one family, all linked to Jolly Joseph. As the investigation unfolds, it uncovers a web of deception, unraveling the dark secrets surrounding the deaths. This documentary takes you through a suspenseful journey, revealing how one woman’s actions led to a series of unimaginable tragedies. It’s a haunting look into a case that still raises questions and sends shivers down the spine.
Prasuk Jain, MD of Snow World & Hospitality
By : Prasuk Jain, Managing Director: Snow World Entertainment & Prasuk Jain Hospitality
“The upcoming budget offers a chance to simplify tax structures for food, beverage, and recreational activities, fostering consumer engagement and operational efficiency. Addressing classifications for automobiles and components can eliminate complexities, ease compliance, and encourage innovation, driving growth across connected industries.”
Can the Budget Revive India’s Growth from 6.4%
1.Macro Indicators: Growth and Fiscal Deficit
- The GDP growth for FY25, as projected by the RBI, stands at 6.76, while the first advance estimates by the government anticipates 6.4%, a four year low. This budget will need to align its policies to reverse the recent slowdown and push GDP growth closer to the earlier aspiration of 7%.
- Fiscal deficit control remains critical. With the FY25 target at 4.9% of GDP, the upcoming budget is expected to tighten this further to approximately 4.3%. However, the depreciating rupee (₹86/$) could be a challenge, on account of the rising global pressures.
2.Infrastructure Spending
- The 2024 budget allocated ₹11.11 lakh crore (3.4% of GDP) to infrastructure, including roads, water, and urban development. For 2025, an even higher allocation is expected to sustain growth momentum. Efficient execution, however, will be the key monitorable factor, addressing delays caused by state elections in the previous year and other administrative challenges.
- Railways are expected to witness continued focus in what can be termed as Railway Capex 2.0, with investments in wagons, new routes, and high-speed rail projects and corridors driving long-term connectivity and economic benefits.
3.Retail Investors and Market Protection
- Retail investor participation in markets has surged, with monthly SIP contributions growing by more than 200% from ₹8,000 crore in 2019 to ₹25,320 crore in 2024. As Nirmala Sitharaman aptly pointed out in 2019, the retail investors’ should not be underestimated with their increasing role in India’s financial ecosystem.
- As the Finance Minister emphasized in earlier budgets, the government remains committed to protecting retail investors. This budget could see measures to further encourage systematic investments while curbing speculative activity with a strong word of caution, as over 93% of retail investors have lost money in the F&O frenzy in three years.
4.Private Sector Push and Capex Revival
Private sector capital expenditure remains below pre-pandemic levels, with a sharp 22% YoY drop in new project announcements. To address this, the budget could introduce:
- Incentives for R&D, such as a National Research Fund and targeted VC funding.
- Capex-linked tax breaks and enhanced depreciation benefits to stimulate investments.
Simplification of tax structures (e.g., lower surcharges and increased minimum tax slab under the new regime) could also spur disposable income and private capex.
5.Green Energy and Mobility
Execution is the buzzword for the EV sector, with policies that should focus on:
- Expanding EV charging infrastructure.
- Enhancing public transport electrification, such as interstate and intrastate electric buses.
Renewable energy storage, such as pump hydro storage, could also see targeted policy support.
6.MSMEs: Bridging Credit Gaps
Addressing supply-side constraints and improving access to formal credit channels remain priorities. Liquidity measures and tax benefits for MSMEs could ease their challenges and ensure their sustained contribution to the economy.
7.Water Infrastructure and River Linkage
- Long-pending projects, could see enhanced clarity on inter-state agreements and execution frameworks, like the ₹40,000 crore Ken-Betwa river linkage. Investments in water infrastructure may accelerate under a broader sustainability agenda.
The Union Budget 2025 is expected to strike a balance between fiscal prudence and growth. With a focus on infrastructure, green energy, and private sector revival, it may signal a pragmatic approach to addressing immediate challenges while laying the foundation for long-term economic progress. The Finance Minister’s commentary will be key in setting the tone for the next fiscal, emphasizing execution as the defining element for 2025. Although the market might see a short term volatility it will remain largely range-bound over the next three months, driven by a mix of cautious optimism, global headwinds and what is expected to be a tepid earning season.
– Hemant Shah, Fund Manager, Seven Islands PMS
Agilus Launches 3-Day Myeloid Malignancies Genomic Test
Delhi, 23nd January 2025: Agilus Diagnostics, India’s largest and most trusted diagnostic network, announces a ground-breaking achievement in genomic testing with its industry-leading 3-day turnaround time (TAT) for test results in myeloid malignancies.
The genomic testing market in India is experiencing rapid growth, driven by advancements in technology, increasing awareness, and the rising demand for personalized medicine. Currently valued at approximately USD 150 million, the market is projected to grow at a CAGR of over 15% in the next five years. Genomic testing is transforming cancer diagnostics by revolutionizing targeted therapy and personalized medicine. By providing actionable insights into an individual’s unique genetic profile, it enables clinicians to identify specific mutations, tailor treatment plans, and select therapies that offer the highest efficacy. As the future of cancer diagnostics, genomic testing empowers early detection, precise interventions, and better disease management, marking a significant shift in how cancer care is delivered. With these advancements, Agilus Diagnostics’ cutting-edge offerings place it at the forefront of this expanding market. By delivering unparalleled speed and precision, the company is well-positioned to capitalize on the growing demand for genomic testing in India, establishing itself as a leader in the space.
Next Generation Sequencing (NGS) is revolutionizing genetic testing by enabling precise, comprehensive analysis of genetic variations, empowering clinicians with actionable insights for personalized patient care. While genomic testing has traditionally been a lengthy process, often taking weeks to deliver results, Agilus Diagnostics has set a new benchmark by delivering individualized reports—meticulously crafted by expert molecular pathologists—in just three days (for myeloid malignancies). This rapid turnaround ensures faster clinical decision-making, ultimately improving patient outcomes and setting us apart as leaders in precision diagnostics.
The Myeloid Genomics Testing and Precision Assay is designed to offer faster, more precise insights into cancer and myeloid disorders. The Myeloid Genomics Testing covers 79 genes, including those linked to inherited risks, to detect key genetic changes like mutations and fusions. This enables personalized treatment recommendations for conditions like Acute Myeloid Leukemia (AML) and Myeloproliferative Neoplasms (MPN). Reports are reviewed by expert pathologists and include internationally recognized risk assessment tools and therapy suggestions tailored to the patient.
The Genomic Profiling Precision Assay provides comprehensive genomic profiling for cancers like lung, colon, breast, and melanoma by analyzing 50 critical genes. It identifies mutations, amplifications, and fusion genes, offering actionable insights for targeted treatments. With optimized panels for tissue and blood samples, the test ensures accurate results within 2 days for liquid biopsy samples and 7 days for tissue block samples, making it a powerful tool for precision medicine.
“Our 3-day genomic testing initiative for myeloid malignancies addresses one of the biggest challenges in precision oncology —Time. With this breakthrough, Agilus Diagnostics is not only setting a new industry standard but also transforming patient care by enabling faster diagnoses and treatment,” said Dr. Anand K, Managing Director & CEO of Agilus Diagnostics.
Currently, the labs in the genomic testing space often take up to 2 -3 weeks to deliver results for myeloid malignancies, which can delay critical clinical decisions. In contrast, Agilus Diagnostics’ rapid testing approach significantly shortens the diagnostic timeline, reducing hospital visits and enhancing the patient experience.
Driving Global Standards in Genomic Testing
Agilus Diagnostics’ commitment to speed and precision extends beyond technological advancements. The company ensures that every report is individualized, with expert molecular pathologists meticulously interpreting results. This personalized reporting approach ensures that physicians receive not just data but clinically actionable insights that support timely and effective patient management.
Agilus Diagnostics is setting new benchmarks in genomic testing, aligning with global standards in personalized medicine. The combination of advanced technology, rapid turnaround times, and expert oversight positions the company as a leader in precision diagnostics. By offering unparalleled speed, accuracy, and patient-focused care, Agilus Diagnostics reaffirms its commitment to bringing world-class diagnostic services to India.
“With our advanced genomic testing capabilities, we aim to provide clinicians with the tools they need to make timely, informed decisions. This not only improves outcomes but also sets a new benchmark for the healthcare industry in India,” added Dr. Anand K.
Adani Says No To Star-Studded Wedding
Prayagraj: 23nd January, 2025: Industrialist Gautam Adani today scorched soaring speculation and buzzing social media rumours that his son Jeet’s upcoming wedding is going to be an extravagant spectacle.
Responding to a media question at Prayagraj if the wedding were going to be a “Maha Kumbh of celebrities,” the billionaire said, “Definitely not!”
In recent days, social media has been awash in reports that a pantheon of global stars and celebrities would be attending Jeet Adani’s wedding with Diva Shah, daughter of Surat diamond merchant Jaimin Shah. The guest names included Elon Musk, Bill Gates, Mark Zuckerberg, Daniel Craig, Taylor Swift, Justin Bieber, Kanye West, the Kardashian sisters, Rafael Nadal, Diljit Dosanjh, Sundar Pichai, Satya Nadella, Billie Eilish, Coldplay and even King Charles and the Pope. Some social media users also said that the India-England ODI at the Motera stadium had been moved to accommodate the wedding, which was expected to feature 1,000 super cars, hundreds of private jets and chefs from 58 countries at a cost of over Rs 10,000 crore.
Speaking after performing the Ganga Aarti with his family at Prayagraj’s Triveni Sangam, Adani said, “My upbringing and our way of doing things are that of a common person from the working class. Jeet too is here for Ma Ganga’s blessings. The wedding will be a simple and traditional family affair.”
Gautam Adani’s announcement that his son’s wedding on 7 February would be a low-key private ceremony in Ahmedabad came during his visit to the Maha Kumbh Mela in Prayagraj. He was accompanied by his wife Dr Priti Adani, sons Karan and Jeet, daughter-in-law Paridhi and granddaughter Kaveri. At the Maha Kumbh, the Adani family offered prayers at the Lete Hanuman Temple after participating in the Mahaprasad Seva at ISKCON, where Adani is supporting the distribution of over one lakh free meals daily. Adani is also giving away one crore prayer books printed by the renowned Gita Press of Gorakhpur.
Calling the Maha Kumbh Mela “an indescribable experience,” the industrialist lavished praise on the Modi and Yogi governments for the arrangements, especially policing and sanitation, and said that the Mela’s successful administration should be studied by management institutes and corporate houses.
BIMTECH Launches India’s First Blockchain Campus Currency
Greater Noida, 23nd January 2025:Birla Institute of Management Technology (BIMTECH), one of India’s leading business schools, proudly introduces its futuristic blockchain-based digital currency, ‘BIMCOIN.’ Specifically designed for BIMTECH’s ecosystem, BIMCOIN facilitates secure, transparent, and instant transactions among students, vendors, and administrators through a permissioned blockchain platform. Following IIT Madras, BIMTECH becomes India’s first business management institute to launch BIMCOIN—ushering fintech innovation in education. BIMTECH and Kalp Decentra Foundation joined forces to launch a cutting-edge Blockchain Learning Centre on campus.
Walking on the path towards the Viksit Bharat 2047 initiative draws inspiration from the Central Bank Digital Currency (CBDC) model and the growing need to merge blockchain technology into real-world plots. Unlike traditional systems, BIMCOIN operates on a blockchain, offering decentralization, transparency, and programmable features like smart contracts.
BIMCOIN streamlines payments, promotes transparency, and introduces advanced financial tools, ensuring enhanced security, fraud protection, and ethical practices. More than a payment solution, BIMCOIN serves as an educational tool, providing students with hands-on experience in blockchain technology, digital currencies, and real-world financial systems.
Dr. Prabina Rajib, Director, BIMTECH, said, “BIMCOIN is more than a payment solution, it is an educational instrument that facilitates our students with practical experience in blockchain technology and digital currencies, shaping their readiness for careers in fintech. This is a significant step in nurturing a culture of innovation and preparing future leaders to thrive in a digital economy. Aligning with Digital India Vision, the digital money leverages permissioned technology with advanced encryption, strict access controls, and data privacy protocols, ensuring the highest security standards.”
The pilot phase was a remarkable success, completing over 1,100 seamless transactions. Challenges, such as technical integration and user onboarding, were addressed through iterative testing and user training. The next phase includes additional rounds of close-net testing before campus-wide implementation. BIMTECH also plans to incorporate this technology into its academic syllabus through courses on blockchain, fintech, and digital innovation, further reinforcing its commitment to advancing education in financial technologies.
Inspired by its founders Late Basant Kumar Birla and Sarala Birla, BIMTECH pioneered innovative programs like PGDM, PGDM-International Business (IB), PGDM-Retail Management (RM), and PGDM-Insurance Business Management (IBM), nurturing individuals into global leaders. Also, BIMTECH is now AACSB accredited, joining the Ivy League of Top Globally Recognized B-Schools. Fostering a symbiotic relationship, the institute excels in management education, supported by its globally placed robust alumni network of over 8000 individuals.
Zydus Receives USFDA Orphan Drug Status for Usnoflast
Ahmedabad, India, January 23, 2025
Zydus, a leading, discovery-based, global pharmaceutical company today announced that the USFDA has granted Orphan Drug Designation (ODD) to Usnoflast, a novel oral NLRP3 inhibitor, for the treatment of amyotrophic lateral sclerosis (ALS). The USFDA’s Office of Orphan Drug Products grants orphan status to support development of medicines for the treatment of rare diseases that affect fewer than 200,000 people in the United States.
Speaking on the development, Chairman of Zydus Lifesciences Limited, Pankaj Patel, said, “This Orphan Drug Designation from the USFDA underlines the urgent need to develop Usnoflast to address Amyotrophic Lateral Sclerosis (ALS), which is a fatal neurodegenerative disease. Zydus is committed to unlocking new frontiers in neuroscience and develop Usnoflast for patients with ALS.”
People living with ALS have an average survival of approximately two to five years from diagnosis, with most ALS patients dying from respiratory failure. ALS patients experience neuroinflammation and rapid neurodegeneration. Axonal neurodegeneration leads to formation of neurofilaments which first accumulate in CSF of ALS patients, and then slowly these neurofilaments enter blood circulation. Owing to rapid neurodegeneration, steady loss of the ability to move, speak, eat, eventually breathe, paralysis and death have been reported in ALS patients. ALS affects approximately 32,000 people in the U.S.A and on an average 5,000 new patients are diagnosed every year with this disease in USA as per statistics from Centre for Disease Control and Prevention (CDC). More than 30,000 people are estimated to be living with ALS in Europe (European Union and United Kingdom), while India has an estimated 75,000 people living with ALS.
Usnoflast (ZYIL1) is a novel, oral small molecule NLRP3 inhibitor. Usnoflast has been studied in several pre-clinical models of neuroinflammation, Parkinson’s disease, Inflammatory Bowel Disease (IBD) and Multiple Sclerosis (MS). The USFDA has earlier granted Zydus an ‘Orphan Drug Designation’ for Usnoflast to treat patients with Cryopyrin Associated Periodic Syndrome (CAPS), a rare auto-inflammatory disease. Zydus has previously completed a Phase 2(a) randomized, double-blind, placebo controlled clinical trial in 24 ALS patients across 7 clinical trial sites in India. [ClinicalTrials.gov Identifier: NCT05981040]. It is planned to present this Phase 2(a) trial data in upcoming medical conference and publish in medical journal. Zydus has recently received approval from USFDA to initiate a randomised, double blind, placebo- controlled Phase 2(b) clinical trial for Usnoflast in patients with Amyotrophic Lateral Sclerosis (ALS).